Abstract | BACKGROUND: It was hypothesized that low-dose aspirin could improve implantation rates in subsequent pregnancies in women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). Previous studies have shown inconclusive results or focused on surrogate endpoints. We therefore conducted a systematic review and meta-analysis of the literature investigating the effect of low-dose aspirin on hard outcomes, including live birth rate, pregnancy rate and miscarriage. METHODS: MEDLINE and EMBASE databases were searched up to November 2011. Randomized controlled trials comparing low-dose aspirin with placebo/no treatment in IVF/ICSI women were included. Pooled odds ratios ( ORs) and 95%confidence intervals (CIs) were calculated. RESULTS: Seventeen studies with 6403 patients were included. The use of aspirin did not improve live birth pregnancy rate compared with placebo or no treatment (1.08; 95% CI, 0.90, 1.29). Pregnancy rates were significantly increased in patients randomized to low-dose aspirin (OR, 1.19; 95% CI, 1.01, 1.39), but miscarriage rates were not (OR, 1.18; 95% CI, 0.82, 1.68). Results of sensitivity analyses including high-quality studies did not show statistically significant differences in all considered endpoints. CONCLUSIONS: The results of this study do not show a substantial efficacy of aspirin inwomen undergoing IVF/ICSI and do not support the use of low-dose aspirin to improve the success of IVF/ICSI in terms of pregnancy outcomes. Further high-quality studies evaluating the possible efficacy of aspirin in selected groups of patients are warranted.
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Authors | F Dentali, W Ageno, E Rezoagli, E Rancan, A Squizzato, S Middeldorp, M Margaglione, E Grandone |
Journal | Journal of thrombosis and haemostasis : JTH
(J Thromb Haemost)
Vol. 10
Issue 10
Pg. 2075-85
(Oct 2012)
ISSN: 1538-7836 [Electronic] England |
PMID | 22900525
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Copyright | © 2012 International Society on Thrombosis and Haemostasis. |
Chemical References |
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Topics |
- Abortion, Spontaneous
(etiology)
- Adult
- Aspirin
(administration & dosage)
- Embryo Implantation
(drug effects)
- Female
- Fertility Agents
(administration & dosage)
- Fertilization in Vitro
(adverse effects)
- Humans
- Live Birth
- Male
- Odds Ratio
- Pregnancy
- Pregnancy Rate
- Sperm Injections, Intracytoplasmic
(adverse effects)
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