Abstract | AIMS: METHODS: A retrospective reivew was conducted of 20 patients diagnosed with APL according to the French - American - British system. After achieving CR and receiving consolidation chemotherapy, nine patients were given maintenance therapy for 1 year (ATRA 45 mg/m(2) /day p.o., mercaptopurine 60 mg/m(2) /day p.o. and ATO 0.15 mg/kg/day × 5 days/week for six cycles in five patients; ATRA 45 mg/m(2) /d p.o. alternating with ATO 0.15 mg/kg/day × 5 days/week in 1 patient; ATRA only in three patients). RESULTS: In all patients the rates of CR, 3-year OS and 5-year OS were 75, 71 and 57%, respectively. For patients treated with ATO maintenance, the rates were 100% for both 5-year OS and 5-year DFS. Four of six patients on ATO maintenance had grade 1 or grade 2 adverse events. Excluding the two patients who died from intracerebral hemorrhage within 4 days after diagnosis, these rates were 85, 82 and 78%, respectively. CONCLUSION: Upfront ATO maintenance therapy for one year is safe and appears to be effective, with the benefits restricted to patients with APL with t(15;17) translocation. Larger studies will be required to confirm this observation.
|
Authors | Yi-Hao Chiang, Yi-Fang Chang, Ruey-Kuen Hsieh, Johnson Lin, Caleb Gonshen Chen, Ken-Hong Lim, Huan-Chau Lin, Ming-Chih Chang |
Journal | Asia-Pacific journal of clinical oncology
(Asia Pac J Clin Oncol)
Vol. 8
Issue 4
Pg. 330-6
(Dec 2012)
ISSN: 1743-7563 [Electronic] Australia |
PMID | 22897350
(Publication Type: Journal Article)
|
Copyright | © 2012 Wiley Publishing Asia Pty Ltd. |
Chemical References |
- Arsenicals
- Oxides
- Tretinoin
- Mercaptopurine
- Arsenic Trioxide
|
Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Arsenic Trioxide
- Arsenicals
(administration & dosage, adverse effects)
- Disease-Free Survival
- Humans
- Leukemia, Promyelocytic, Acute
(diagnosis, drug therapy, therapy)
- Maintenance Chemotherapy
- Male
- Mercaptopurine
(administration & dosage, adverse effects)
- Middle Aged
- Oxides
(administration & dosage, adverse effects)
- Retrospective Studies
- Tretinoin
(administration & dosage, adverse effects)
|