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Prediction of preeclampsia by combining serum histidine-rich glycoprotein and uterine artery Doppler.

AbstractBACKGROUND:
Preeclampsia is associated with both maternal and perinatal morbidity and mortality. Histidine-rich glycoprotein (HRG) is a protein interacting with angiogenesis, coagulation, and inflammatory responses, processes known to be altered in preeclamptic pregnancies. Significantly lower levels of HRG have been demonstrated as early as in the first trimester in women later developing preeclampsia compared with normal pregnancies. The aim of this study was to investigate whether the combination of HRG and uterine artery Doppler ultrasonography can be used as a predictor of preeclampsia.
METHODS:
A total of 175 women were randomly selected from a case-control study; 86 women had an uncomplicated pregnancy and 89 women later developed preeclampsia. Blood samples and pulsatility index (PI) were obtained from both cases and controls in gestational week 14.
RESULTS:
HRG levels were significantly lower in women who developed preterm preeclampsia compared with controls, but not for women developing preeclampsia in general. PI was significantly higher in the preeclampsia group compared with controls, especially in preterm preeclampsia. The combination of HRG and PI revealed a sensitivity of 91% and a specificity of 62% for preterm preeclampsia.
CONCLUSIONS:
The combination of HRG and uterine artery Doppler may predict preterm preeclampsia in early pregnancy.
AuthorsMarie Bolin, Anna-Karin Wikström, Eva Wiberg-Itzel, Anna-Karin Olsson, Maria Ringvall, Inger Sundström-Poromaa, Ove Axelsson, Basky Thilaganathan, Helena Åkerud
JournalAmerican journal of hypertension (Am J Hypertens) Vol. 25 Issue 12 Pg. 1305-10 (Dec 2012) ISSN: 1941-7225 [Electronic] United States
PMID22895448 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers
  • Proteins
  • histidine-rich proteins
Topics
  • Adult
  • Biomarkers (blood)
  • Case-Control Studies
  • Chi-Square Distribution
  • Down-Regulation
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Gestational Age
  • Humans
  • Pre-Eclampsia (blood, diagnosis, diagnostic imaging, physiopathology)
  • Predictive Value of Tests
  • Pregnancy
  • Proteins (analysis)
  • Pulsatile Flow
  • Sensitivity and Specificity
  • Ultrasonography, Doppler
  • Uterine Artery (diagnostic imaging, physiopathology)

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