Abstract |
In therapy of the metabolic syndrome, the optimal dietary approach with regard to its macronutrient composition and metabolically favourable food components, such as the plant-derived n-3 fatty acid α- linolenic acid (ALA), is still a matter of debate. We investigated the effects of a hypoenergetic diet with low energy density (ED) enriched in rapeseed oil, resulting in high MUFA content and an ALA intake of 3.5 g/d on body weight and cardiovascular risk profile in eighty-one patients with the metabolic syndrome in comparison with an olive oil diet rich in MUFA, but with a low ALA content. After a 6-month dietary intervention, body weight was significantly reduced in the rapeseed oil and olive oil groups ( -7.8 v. -6.0 kg; P < 0.05). There were significant decreases in systolic blood pressure, total cholesterol and LDL-cholesterol, and insulin levels in both groups (P < 0.05). For all of these changes, no inter-group differences were observed. After the rapeseed oil diet, diastolic blood pressure declined more than after the olive oil diet (P < 0.05 for time × group interaction). Furthermore, concentrations of serum TAG were significantly reduced after the high ALA intake, but not in the low ALA group (P < 0.05 for time × group interaction). In conclusion, our dietary food pattern with a low ED and high intakes of MUFA and ALA may be a practical approach for long-term dietary treatment in patients with the metabolic syndrome, leading to weight reduction and an improvement in the overall cardiovascular risk profile.
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Authors | Andrea Baxheinrich, Bernd Stratmann, Young Hee Lee-Barkey, Diethelm Tschoepe, Ursel Wahrburg |
Journal | The British journal of nutrition
(Br J Nutr)
Vol. 108
Issue 4
Pg. 682-91
(Aug 2012)
ISSN: 1475-2662 [Electronic] England |
PMID | 22894911
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fatty Acids, Monounsaturated
- Plant Oils
- Rapeseed Oil
- alpha-Linolenic Acid
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Topics |
- Adult
- Brassica rapa
(chemistry)
- Cardiovascular Diseases
(epidemiology, prevention & control)
- Diet, Reducing
(methods)
- Fatty Acids, Monounsaturated
- Feasibility Studies
- Female
- Germany
(epidemiology)
- Humans
- Hyperlipidemias
(prevention & control)
- Hypertension
(prevention & control)
- Male
- Metabolic Syndrome
(diet therapy)
- Middle Aged
- Patient Compliance
- Patient Dropouts
- Plant Oils
(chemistry, therapeutic use)
- Prevalence
- Rapeseed Oil
- Risk Factors
- Seeds
(chemistry)
- Weight Loss
- alpha-Linolenic Acid
(analysis, therapeutic use)
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