Metastatic neuroendocrine carcinoma presenting as a "Superscan" on 68Ga-DOTANOC somatostatin receptor PET/CT.

Abstract

PET/CT imaging using Ga-labeled somatostatin analogs has become a popular noninvasive diagnostic modality in the workup of patients with neuroendocrine tumors. A 65-year-old man with pancreatic neuroendocrine tumor with confirmed liver metastases on conventional imaging underwent restaging Ga-DOTANOC PET/CT to monitor response to cold octreotide therapy. Previous PET/CT had shown presence of multiple liver and skeletal metastases along with a primary pancreatic tumor showing intense tracer uptake. The present PET/CT study showed an increase in number and uptake of the metastatic lesions suggestive of progressive disease resulting in the appearance of a superscan.

• Authors: Niraj Naswa, Sellam Karunanithi, Ramya Soundararajan, Kalpa Jyoti Das, Krishan Kant Agarwal, Arun Malhotra, Chandrasekhar Bal, Rakesh Kumar
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 37 Issue 9 Pg. 892-4 (Sep 2012) ISSN: 1536-0229 [Electronic] United States
• PMID: 22889781 (Publication Type: Case Reports, Journal Article)

Chemical References

• 68Ga-DOTANOC
• Organometallic Compounds
• Receptors, Somatostatin

Topics

• Aged
• Carcinoma, Neuroendocrine (diagnostic imaging, pathology)
• Humans
• Male
• Multimodal Imaging
• Neoplasm Metastasis
• Organometallic Compounds
• Positron-Emission Tomography
• Receptors, Somatostatin (metabolism)
• Tomography, X-Ray Computed