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Efficacy of intra-umbilical oxytocin in the management of retained placenta: a randomized controlled trial.

AbstractAIM:
Retained placenta is an important cause of maternal mortality. The present study was aimed to determine the efficacy of umbilical injection of oxytocin as a treatment modality in this condition.
MATERIAL AND METHODS:
This was a single-center randomized controlled trial incorporating 58 women with retained placenta of more than 30 min, equally distributed into two study arms of intra-umbilical injection of oxytocin (50 IU oxytocin diluted with normal saline [NS] to a total volume 30 mL) and intra-umbilical injection of NS (30 mL). Primary outcome was expulsion of the placenta within 30 min following intervention. All the data were analyzed on an intention-to-treat basis.
RESULTS:
The success rate in the intra-umbilical oxytocin group was 51.72% compared to 20.69% in the control arm. This difference in the primary outcome was statistically significant with a P-value<0.05 (P=0.014) favoring intra-umbilical oxytocin infusion with an efficacy rate of 1.5 and a number-needed-to-treat of 3. The peripartum bleeding complications were more in the NS group with a statistically higher (P<0.001) requirement of extra oxytocin to control post-partum bleeding. There were no differences between the two groups in respect to other secondary outcomes, such as post-partum fever, antibiotic requirement and hospital stay.
CONCLUSION:
  Umbilical vein injection of 50IU oxytocin in 30mL of NS delivered effectively via the umbilical cord with milking in cases of retained placenta seems a simple and promising technique to reduce the incidence of a potentially morbid procedure and other complications.
AuthorsAjanta Samanta, Samir Ghosh Roy, Pallab Kumar Mistri, Anirban Mitra, Ranjan Pal, Animesh Naskar, Sanjay Kumar Bhattacharya, Partha Pratim Pal, Arindam Pande
JournalThe journal of obstetrics and gynaecology research (J Obstet Gynaecol Res) Vol. 39 Issue 1 Pg. 75-82 (Jan 2013) ISSN: 1447-0756 [Electronic] Australia
PMID22889466 (Publication Type: Journal Article, Randomized Controlled Trial)
Copyright© 2012 The Authors. Journal of Obstetrics and Gynaecology Research © 2012 Japan Society of Obstetrics and Gynecology.
Chemical References
  • Oxytocics
  • Oxytocin
Topics
  • Adult
  • Female
  • Humans
  • Injections, Intravenous
  • Oxytocics (administration & dosage, therapeutic use)
  • Oxytocin (administration & dosage, therapeutic use)
  • Placenta, Retained (drug therapy)
  • Pregnancy
  • Treatment Outcome
  • Umbilical Veins

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