Primary Sjögren's syndrome and B-non-Hodgkin lymphoma: role of CD4+ T lymphocytopenia.

Abstract

Primary Sjögren's syndrome (PSS) is associated with increased risk of lymphoproliferative malignancy, and B-cell non-Hodgkin lymphoma (B-NHL) is the most frequent type. To evaluate CD4+ T lymphocytes distributions in patients with (PSS) and the association of CD4+ T lymphocytopenia with the development of (B-NHL), this study included 8 (PSS) patients associated with B-NHL (group I), 50 (pSS) patients without B-NHL (group II), and 30 healthy volunteers who served as controls. The frequency of circulating CD4+ and CD8+ T lymphocytes distributions and CD4+/CD8+ T cell ratio was assessed using flow cytometry coulter EPICS-XL and compared between patients groups and controls. There was statistically significant CD4+ T lymphocytopenia in (PSS) patients with B-NHL than those without lymphoma and controls (P = 0.001). Moreover, a significant low CD4+/CD8+ T cell ratio 0.8 in group I than group II and controls (P = 0.001) was found. Significant positive correlations of CD4+ T lymphocytopenia with other risk factors (parotid swelling, vasculitis, rheumatoid factors, low complement, cryoglobulinemia) were detected. CD4+ T lymphocytopenia is associated with B-NHL developed in patients with PSS and can be considered as an important predictor of lymphoma.

• Authors: Faten Ismail, Amel Mahmoud, Hisham Abdelhaleem, Amro Mamdoh, M Geneidy, Enas Kamal
• Journal: Rheumatology international (Rheumatol Int) Vol. 33 Issue 4 Pg. 1021-5 (Apr 2013) ISSN: 1437-160X [Electronic] Germany
• PMID: 22886469 (Publication Type: Journal Article)

Topics

• Adult
• CD4-Positive T-Lymphocytes (immunology, pathology)
• Female
• Humans
• Lymphocyte Count
• Lymphoma, Non-Hodgkin (etiology, immunology, pathology)
• Male
• Middle Aged
• Risk Factors
• Sjogren's Syndrome (etiology, immunology, pathology)
• T-Lymphocytopenia, Idiopathic CD4-Positive (complications, immunology, pathology)