Abstract | INTRODUCTION: MATERIALS AND METHODS: A comprehensive computer literature search of studies published up to 31 January 2012 regarding (18)F-DOPA PET or PET/CT in patients with CHI was performed. Pooled sensitivity and specificity, area under the ROC curve and diagnostic odds ratio (DOR) of (18)F-DOPA PET or PET/CT in diagnosing focal CHI were calculated. The localization accuracy of focal CHI was also estimated. Seven studies comprising 195 CHI patients were included. RESULTS: The pooled sensitivity and specificity of (18)F-DOPA PET or PET/CT in differentiating between focal and diffuse CHI were 89% (95% confidence interval [CI]:81-95%) and 98% (95% CI:89-100%), respectively. The DOR was 74.5 (95% CI:18-307). The area under the ROC curve was 0.95. The pooled accuracy of these functional imaging methods in localizing focal CHI was 80% (95% CI:71-88%). DISCUSSION: In CHI patients, (18)F-DOPA PET or PET/CT demonstrated high sensitivity and specificity in differentiating between focal and diffuse CHI. (18)F-DOPA PET or PET/CT are accurate methods of localizing focal CHI. Nevertheless, possible sources of false-negative results for focal CHI should be kept in mind.
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Authors | Giorgio Treglia, Paoletta Mirk, Alessandro Giordano, Vittoria Rufini |
Journal | Pediatric radiology
(Pediatr Radiol)
Vol. 42
Issue 11
Pg. 1372-9
(Nov 2012)
ISSN: 1432-1998 [Electronic] Germany |
PMID | 22885604
(Publication Type: Journal Article, Meta-Analysis, Review)
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Chemical References |
- Radiopharmaceuticals
- fluorodopa F 18
- Dihydroxyphenylalanine
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Topics |
- Congenital Hyperinsulinism
(diagnostic imaging, epidemiology)
- Dihydroxyphenylalanine
(analogs & derivatives)
- Evidence-Based Medicine
- Humans
- Positron-Emission Tomography
(statistics & numerical data)
- Prevalence
- Radiopharmaceuticals
- Reproducibility of Results
- Risk Factors
- Sensitivity and Specificity
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