Effects of partial portal vein arterialization on liver regeneration after hepatectomy in minipigs with obstructive jaundice.

Abstract

BACKGROUND:

Hilar cholangiocarcinoma is a malignant tumor that is difficult to cure. The aim of this study was to observe the effects of flow-controlled partial portal vein arterializations (PPVA) on liver regeneration after hepatectomy in minipigs with chronic obstructive jaundice.

METHODS:

Eight minipigs were made into chronic obstructive jaundice models. United semi-hepatectomy, which imitates extended radical surgery for treatment of hilar cholangiocarcinoma, was then performed. The eight minipigs were randomly divided into groups A and B (n = 4 minipigs each). PPVA was performed in Group A but not in Group B. The effects of flow-controlled PPVA on live regeneration after hepatectomy were observed for 30 days after hepatectomy.

RESULTS:

The portal vein PO(2) at the immediate time point and on postoperative day 30 was higher in Group A ((47.33 ± 2.43) and (48.50 ± 4.44) mmHg) than in Group B ((35.38 ± 4.06) and (35.55 ± 2.55) mmHg respectively, all P < 0.01). The mitotic index of liver cells on postoperative days 14 and 21 was higher in Group A (12.55% ± 2.85% and 15.25% ± 1.99% respectively) than in Group B (6.85% ± 2.10% and 11.88% ± 1.15% respectively, all P < 0.05). The regeneration rate of residual liver on postoperative days 14 and 21 was higher in Group A (24.56% ± 6.15% and 70.63% ± 9.83% respectively) than in Group B (11.96% ± 5.43% and 44.92% ± 7.42% respectively, P < 0.05 and P < 0.01 respectively).

CONCLUSION:

Flow-controlled PPVA can promote liver regeneration after hepatectomy and prevent liver failure in minipigs with chronic obstructive jaundice.

• Authors: Yong-Liang Chen, Wen-Bin Chen, Yun-Yan Wan, Wen-Gang Li, Zhi-Qiang Huang, Xiao-Tong Wu, Jie Yang, Li Yang
• Journal: Chinese medical journal (Chin Med J (Engl)) Vol. 125 Issue 13 Pg. 2302-5 (Jul 2012) ISSN: 2542-5641 [Electronic] China
• PMID: 22882852 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acepromazine
• Ketamine
• Atropine

Topics

• Acepromazine (therapeutic use)
• Animals
• Arteriovenous Shunt, Surgical (methods)
• Atropine (therapeutic use)
• Female
• Hepatectomy (methods)
• Jaundice, Obstructive (surgery)
• Ketamine (therapeutic use)
• Liver Regeneration (physiology)
• Portal Vein (surgery)
• Swine
• Swine, Miniature