[Effect of a synthetic somatostatin analogue with delayed action (SMS 201-995) on the biliary expenditure in a patient with an external biliary tract fistula].

Abstract

The effect of treatment with a long acting analogue of somatostatin (SMS 201-995) administered by subcutaneous route 165 micrograms every eight hours in a patient with a external biliary fistula is reported. There was a significant reduction of the daily fistula output during treatment when compared with the basal periods (p = 0.04), with an average decrease of 270 ml/day during the first period of treatment and 357 ml/day when the drug was administered the second time (p = 0.04). There where not changes in the chemical composition of the bile neither adverse side effects were observed during treatment. These results suggest that SMS 201-995 might be useful in the treatment of external biliary fistulas.

• Authors: R Miranda-Ruiz, J Castañón-González, C Pérez Aldana, E Arias, M Díaz de León Ponce, A Zárate
• Journal: Revista de gastroenterologia de Mexico (Rev Gastroenterol Mex) 1990 Apr-Jun Vol. 55 Issue 2 Pg. 67-9 ISSN: 0375-0906 [Print] Mexico
• Vernacular Title: Efecto de un análogo sintético de somatostatina de acción prolongada (SMS 201-995) sobre el gasto biliar en un paciente con una fístula externa de las vías biliares.
• PMID: 2287871 (Publication Type: Case Reports, Journal Article)

Chemical References

• Delayed-Action Preparations
• Octreotide

Topics

• Adult
• Bile (metabolism)
• Biliary Fistula (drug therapy, physiopathology)
• Delayed-Action Preparations
• Fistula (drug therapy, physiopathology)
• Humans
• Male
• Octreotide (therapeutic use)
• Skin Diseases (drug therapy, physiopathology)