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Thalidomide for steroid-dependent immune reconstitution inflammatory syndromes during AIDS.

Abstract
Management of relapsing or refractory immune reconstitution inflammatory syndromes (IRISs) despite corticosteroid therapy is yet to be defined. We describe three HIV-infected patients with corticosteroid-dependent and life-threatening paradoxical immune reconstitution inflammatory syndrome for whom thalidomide treatment induced rapid clinical remission and permitted complete corticosteroid withdrawal without clinical relapse.
AuthorsAnne-Sophie Brunel, Jacques Reynes, Edouard Tuaillon, Pierre-Alain Rubbo, Olivier Lortholary, Brigitte Montes, Vincent Le Moing, Alain Makinson
JournalAIDS (London, England) (AIDS) Vol. 26 Issue 16 Pg. 2110-2 (Oct 23 2012) ISSN: 1473-5571 [Electronic] England
PMID22874513 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Immunosuppressive Agents
  • Steroids
  • Thalidomide
Topics
  • AIDS-Related Opportunistic Infections (drug therapy, immunology)
  • Acquired Immunodeficiency Syndrome (drug therapy, immunology)
  • Adult
  • Antiretroviral Therapy, Highly Active
  • Female
  • Humans
  • Immune Reconstitution Inflammatory Syndrome (drug therapy, immunology)
  • Immunosuppressive Agents (pharmacology)
  • Male
  • Meningitis, Cryptococcal (drug therapy, immunology)
  • Middle Aged
  • Recurrence
  • Steroids (therapeutic use)
  • Thalidomide (pharmacology)
  • Treatment Outcome
  • Tuberculosis (drug therapy, immunology)

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