Abstract | RATIONALE: OBJECTIVE: METHODS AND RESULTS: Mice deficient in LDL receptor (Ldlr(-/-)) and mice lacking both TGH and LDLR (Tgh(-/-)/Ldlr(-/-)) were fed with a Western-type diet for 12 weeks. Analysis of Tgh(-/-)/Ldlr(-/-) plasma showed an atheroprotective lipoprotein profile with decreased cholesterol in the VLDL and the LDL fractions, concomitant with elevated high-density lipoprotein cholesterol. Significantly reduced plasma apolipoprotein B levels were also observed in Tgh(-/-)/Ldlr(-/-) mice. Consequently, Tgh(-/-)/Ldlr(-/-) mice presented with a significant reduction (54%, P<0.01) of the high-fat, high- cholesterol dieteninduced atherosclerotic plaques when compared with Tgh(+/+)/Ldlr(-/-) mice in the cross-sectional aortic root analysis. TGH deficiency did not further increase liver steatosis despite lowering plasma lipids, mainly due to reduced hepatic lipogenesis. The ameliorated dyslipidemia in Tgh(-/-)/Ldlr(-/-) mice was accompanied with significantly improved insulin sensitivity. CONCLUSIONS:
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Authors | Jihong Lian, Ariel D Quiroga, Lena Li, Richard Lehner |
Journal | Circulation research
(Circ Res)
Vol. 111
Issue 8
Pg. 982-90
(Sep 28 2012)
ISSN: 1524-4571 [Electronic] United States |
PMID | 22872154
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Apolipoproteins B
- Blood Glucose
- Cholesterol, HDL
- Cholesterol, LDL
- Cholesterol, VLDL
- Fatty Acids
- Insulin
- Receptors, LDL
- Lipase
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Topics |
- Animals
- Aorta
(metabolism, pathology)
- Apolipoproteins B
(blood)
- Blood Glucose
(metabolism)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Cholesterol, VLDL
(blood)
- Coronary Artery Disease
(genetics, metabolism, pathology)
- Disease Models, Animal
- Dyslipidemias
(genetics, metabolism)
- Fatty Acids
(metabolism)
- Fatty Liver
(genetics, metabolism, pathology)
- Female
- Insulin
(blood)
- Insulin Resistance
(physiology)
- Lipase
(deficiency, genetics, metabolism)
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Receptors, LDL
(genetics, metabolism)
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