Anticoagulant, fibrinolytic, and hypoglycemic effects of tetrapeptide Arg-Pro-Gly-Pro.

Abstract

It was found that 3-fold intranasal administration of Arg-Pro-Gly-Pro peptide in a dose of 1 mg/kg body weight under conditions of experimental persistent hyperglycemia prevents the development of diabetes in experimental rats and produces normoglycemic, anticoagulant, fibrinolytic, and antiplatelet effects.

• Authors: T A Shubina, N F Myasoedov, L A Andreeva, L A Lyapina, A M Ulyanov, T J Obergan, V E Pastorova
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 153 Issue 3 Pg. 327-30 (Jul 2012) ISSN: 1573-8221 [Electronic] United States
• PMID: 22866303 (Publication Type: Journal Article)

Chemical References

• Anticoagulants
• Arg-Pro-Gly-Pro
• Hypoglycemic Agents
• Oligopeptides

Topics

• Administration, Intranasal
• Animals
• Anticoagulants (administration & dosage, therapeutic use)
• Fibrinolysis (drug effects)
• Hyperglycemia (drug therapy)
• Hypoglycemic Agents (administration & dosage, therapeutic use)
• Male
• Oligopeptides (administration & dosage, therapeutic use)
• Rats