Abstract | OBJECTIVE: DESIGN: Cohort study. SETTING: University hospital. PATIENTS: All consecutive women aged ≤35 years admitted to our IVF unit from January 2011 to October 2011 who reached the ovum pick-up stage. INTERVENTIONS: Triggering final oocytes maturation by GnRH-ag instead of hCG, in high-responder patients undergoing either the ultrashort GnRH-ag/ GnRH-ant or the multidose GnRH-antagonist controlled ovarian hyperstimulation (COH) protocols. MAIN OUTCOME MEASURES: Ovarian stimulation characteristics, percentage of mature oocytes, fertilization and pregnancy rates. RESULTS: No inbetween groups differences were observed in ovarian-stimulation related variable, percentage of mature oocytes, fertilization or pregnancy rates. No case of moderate-severe OHSS was reported in the study, or the control groups. CONCLUSIONS: Three consecutive doses of daily GnRH-ag administration at the beginning of ultrashort flare GnRH-ag/ GnRH-ant COH protocol, did not interfere with the ability of the GnRH-ag to trigger final oocytes maturation at the end of the COH cycle.
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Authors | Raoul Orvieto, Ravit Nahum, Efraim Zohav, Gad Liberty, Eyal Y Anteby, Simion Meltcer |
Journal | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
(Gynecol Endocrinol)
Vol. 29
Issue 1
Pg. 51-3
(Jan 2013)
ISSN: 1473-0766 [Electronic] England |
PMID | 22857268
(Publication Type: Journal Article)
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Chemical References |
- Gonadotropins
- Luteolytic Agents
- Triptorelin Pamoate
- Gonadotropin-Releasing Hormone
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Topics |
- Adult
- Cohort Studies
- Databases, Factual
- Female
- Fertilization
(drug effects)
- Fertilization in Vitro
(methods)
- Gonadotropin-Releasing Hormone
(agonists, antagonists & inhibitors)
- Gonadotropins
(administration & dosage)
- Humans
- Infertility, Female
(drug therapy, epidemiology)
- Luteolytic Agents
(administration & dosage)
- Oocytes
(cytology, drug effects)
- Ovarian Hyperstimulation Syndrome
(epidemiology, prevention & control)
- Ovulation
(drug effects, physiology)
- Ovulation Induction
(methods)
- Pregnancy
- Pregnancy Rate
- Risk Factors
- Triptorelin Pamoate
(administration & dosage)
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