Treatment of refractory orbital pseudotumors with pulsed chemotherapy.

Abstract

Five patients with orbital pseudotumor refractive to initial therapy are discussed. Three had a destructive granulomatous process associated with a sclerosing component. Two exhibited a predominantly lymphocytic infiltration. Chemotherapy with Prednisone (100 mg/day) and either Cytoxan (100 mg/day) or Chlorambucil (10 mg/day) in 5-day pulses is described. All patients responded clinically to this treatment without unfavorable side effects.

• Authors: G L Paris, G F Waltuch, P R Egbert
• Journal: Ophthalmic plastic and reconstructive surgery (Ophthalmic Plast Reconstr Surg) Vol. 6 Issue 2 Pg. 96-101 ( 1990) ISSN: 0740-9303 [Print] United States
• PMID: 2285671 (Publication Type: Journal Article)

Chemical References

• Chlorambucil
• Cyclophosphamide
• Prednisone

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Chlorambucil (administration & dosage)
• Combined Modality Therapy
• Cyclophosphamide (administration & dosage)
• Female
• Fibrosis
• Humans
• Male
• Middle Aged
• Orbit (pathology)
• Orbital Neoplasms (drug therapy, pathology)
• Prednisone (administration & dosage)