Abstract | OBJECTIVE: DATA SOURCES: STUDY SELECTION AND DATA EXTRACTION: Only English-language publications were included. Randomized controlled trial data, observational studies, case reports, package labeling, and commentaries regarding men with BPH/LUTS using inhaled anticholinergic agents and the associated development of urinary retention were reviewed. DATA SYNTHESIS: Two case reports; 1 prospective, open-label, single-arm study; and 2 nested case-control studies evaluated or described the use of inhaled anticholinergic agents and the development of acute urinary retention in men with BPH/LUTS. Taken together, the available data demonstrate that treatment with inhaled anticholinergic agents is associated with acute urinary retention in men with preexisting LUTS or BPH. CONCLUSIONS: Men with LUTS or BPH who are treated with inhaled anticholinergic agents may develop acute urinary retention, but this cannot be quantified based on the limited information available. Inhaled anticholinergic agents should be used when indicated in men with LUTS or BPH, but close monitoring and patient education should be implemented.
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Authors | Joseph P Vande Griend, Sunny A Linnebur |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 46
Issue 9
Pg. 1245-9
(Sep 2012)
ISSN: 1542-6270 [Electronic] United States |
PMID | 22851743
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Administration, Inhalation
- Cholinergic Antagonists
(administration & dosage, adverse effects)
- Humans
- Lower Urinary Tract Symptoms
(complications, drug therapy)
- Male
- Prostatic Hyperplasia
(complications, drug therapy)
- Urinary Retention
(chemically induced)
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