Class 3 semaphorins as a therapeutic target.

Abstract

INTRODUCTION:

The semaphorins were initially described as axon guidance molecules that play important roles in the development of nervous system. Recent studies suggest that semaphorins and their receptors also exert such diverse functions as immune response, control of vascular endothelial cell motility and invasion of many types of cancer cells.

AREAS COVERED:

The available results concerning application of class 3 semaphorins and their inhibitors for the treatment in animal disease models.

EXPERT OPINION:

Because semaphorins are now recognized as key players in immune, cardiovascular, bone metabolism and neurological system, semaphorins and their receptors are most promising therapeutic targets for various disease states. As semaphorins exert their diverse or even opposing activities in vivo, more elaborate studies on pathophysiology and signal transduction mechanisms of semaphorins are required.

• Authors: Yoshio Goshima, Yukio Sasaki, Naoya Yamashita, Fumio Nakamura
• Journal: Expert opinion on therapeutic targets (Expert Opin Ther Targets) Vol. 16 Issue 9 Pg. 933-44 (Sep 2012) ISSN: 1744-7631 [Electronic] England
• PMID: 22834859 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Semaphorins

Topics

• Animals
• Gene Expression Regulation (drug effects, physiology)
• Humans
• Models, Molecular
• Protein Conformation
• Semaphorins (chemistry, genetics, metabolism)
• Signal Transduction (drug effects, physiology)