Biodistribution of ultra small gadolinium-based nanoparticles as theranostic agent: application to brain tumors.

Abstract

Gadolinium-based nanoparticles are novel objects with interesting physical properties, allowing their use for diagnostic and therapeutic applications. Gadolinium-based nanoparticles were imaged following intravenous injection in healthy rats and rats grafted with 9L gliosarcoma tumors using magnetic resonance imaging and scintigraphic imaging. Quantitative biodistribution using gamma-counting of each sampled organ confirmed that these nanoparticles were rapidly cleared essentially by renal excretion. Accumulation of these nanoparticles in 9L gliosarcoma tumors implanted in the rat brain was quantitated. This passive and long-duration accumulation of gadolinium-based nanoparticles in tumor, which is related to disruption of the blood-brain barrier, is in good agreement with the use of these nanoparticles as radiosensitizers for brain tumors.

• Authors: Imen Miladi, Géraldine Le Duc, David Kryza, Aurélie Berniard, Pierre Mowat, Stéphane Roux, Jacqueline Taleb, Pauline Bonazza, Pascal Perriat, François Lux, Olivier Tillement, Claire Billotey, Marc Janier
• Journal: Journal of biomaterials applications (J Biomater Appl) Vol. 28 Issue 3 Pg. 385-94 (Sep 2013) ISSN: 1530-8022 [Electronic] England
• PMID: 22832216 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Gadolinium

Topics

• Animals
• Brain Neoplasms (drug therapy)
• Gadolinium (pharmacokinetics)
• Humans
• Magnetic Resonance Imaging
• Nanoparticles (therapeutic use)
• Rats
• Tissue Distribution
• Tomography, Emission-Computed, Single-Photon
• Tomography, X-Ray Computed