Abstract | OBJECTIVE: PATIENTS AND METHODS: A prospective multicenter study of imidafenacin 0.1 mg twice daily for patients with OAB and nocturia was conducted. At baseline and at week 4 and 8, patients were assessed using the overactive bladder symptom score (OABSS), frequency volume charts (FVC) and the Pittsburgh Sleep Quality Index (PSQI). RESULTS: Treatment with imidafenacin significantly improved OAB symptoms. Imidafenacin also improved PSQI, especially subjective sleep quality, sleep latency and daytime dysfunction. In FVC, the number of daytime voids and nighttime voids significantly decreased and average voided volume significantly increased after imidafenacin. Subanalysis of FVC based on the patients' age revealed that nocturnal polyuria was more often found in patients aged 75 years or over than in those aged under 75 years (79 vs. 55%, p < 0.05). Treatment with imidafenacin significantly reduced the nocturnal polyuria index only in patients aged 75 years or over. CONCLUSIONS:
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Authors | Naoki Wada, Masaki Watanabe, Masafumi Kita, Seiji Matsumoto, Hiroaki Osanai, Satoshi Yamaguchi, Atsushi Numata, Makoto Fujisawa, Yuji Saga, Kyokushin Hou, Hiromitsu Iuchi, Daisuke Niibori, Tatsuhiko Kura, Akihisa Taniguchi, Manabu Kunieda, Yasunobu Nakata, Hidehiro Kakizaki |
Journal | Urologia internationalis
(Urol Int)
Vol. 89
Issue 2
Pg. 215-21
( 2012)
ISSN: 1423-0399 [Electronic] Switzerland |
PMID | 22832092
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 S. Karger AG, Basel. |
Chemical References |
- Imidazoles
- Muscarinic Antagonists
- imidafenacin
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Topics |
- Aged
- Aged, 80 and over
- Female
- Humans
- Imidazoles
(pharmacology)
- Male
- Middle Aged
- Muscarinic Antagonists
(pharmacology)
- Nocturia
(drug therapy)
- Polyuria
(drug therapy)
- Sleep
(drug effects)
- Sleep Wake Disorders
(drug therapy)
- Time Factors
- Urinary Bladder, Overactive
(drug therapy)
- Urodynamics
(drug effects)
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