Current trends in the chemotherapy of colorectal cancer.

Abstract

The increase in the therapeutic arsenal in the last 20 years, has given rise to changes in treating colorectal cancer (CRC) with only pyrimidines to combine several cytotoxic drugs. However, the present question is to determine the optimal sequence of this combination. This review presents an update of data on chemical and clinical features of chemotherapy used for colorectal cancer and the mechanisms of cellular resistance and potential predictive and prognostic biomarkers, which may contribute to a better selection of a therapeutic strategy.

• Authors: M A Berciano-Guerrero, J C Villa-Guzmán, R Acosta-Guerrero, G Castañeda-Peñalvo, J Rodríguez-Flores
• Journal: Current medicinal chemistry (Curr Med Chem) Vol. 19 Issue 26 Pg. 4414-30 ( 2012) ISSN: 1875-533X [Electronic] United Arab Emirates
• PMID: 22830343 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antineoplastic Agents

Topics

• Aged
• Aged, 80 and over
• Antineoplastic Agents (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Colorectal Neoplasms (drug therapy)
• Drug Therapy (trends)
• Humans
• Prognosis