Abstract | BACKGROUND: OBJECTIVE: Sensitization prevalence was sought, and several patch testing concentrations and vehicles were compared. METHODS: One hundred forty-two patients tested to the standard screening series for evaluation of dermatitis consented to additional tests including BAK 0.15% aqueous (aq), BAK 0.15% petrolatum (pet), BEC 0.15% aq, and BEC 0.5% aq. Follow-up to assess clinical relevancy included early and late patch test reads, 1-month clinical follow-up, and long-term phone calls. Patients were categorized as definite, possible, or unlikely to have ACD to BAK and/or BEC. RESULTS: Atopy was not associated with patch test reactions (P = 0.154). Seventy-five percent (6/8) of the patients with possible ACD to BAK had coreactions with BEC. Testing to both BAK 0.15% pet and 0.15% aq would have identified 91% of those with possible ACD to BAK, twice as many than if only BAK 0.1% aq from the standard series was used. CONCLUSION: Sensitization to BAK and BEC, although rare, does occur. Weak and morphologically irritant reactions at day 7 reading can be relevant. We recommend testing to BAK 0.15% aq and 0.15% pet to increase sensitivity and having patients undergo long-term follow-up.
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Authors | Harry Dao Jr, Chris Fricker, Susan T Nedorost |
Journal | Dermatitis : contact, atopic, occupational, drug
(Dermatitis)
2012 Jul-Aug
Vol. 23
Issue 4
Pg. 162-6
ISSN: 2162-5220 [Electronic] United States |
PMID | 22828255
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Allergens
- Benzalkonium Compounds
- Irritants
- Preservatives, Pharmaceutical
- Benzethonium
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Allergens
(immunology)
- Benzalkonium Compounds
(adverse effects)
- Benzethonium
(adverse effects)
- Child
- Dermatitis, Allergic Contact
(etiology, immunology)
- Female
- Humans
- Irritants
(immunology)
- Male
- Middle Aged
- Patch Tests
(methods)
- Preservatives, Pharmaceutical
(adverse effects)
- Prevalence
- Young Adult
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