Pregnancy outcome in anti-N-methyl-D-aspartate receptor encephalitis.

Abstract

BACKGROUND:

Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is an autoimmune disorder resulting in neurologic and psychiatric symptoms. Treatment is challenging in pregnancy, because little data exist to guide management.

CASE:

A 24-year-old woman with a known diagnosis of anti-NMDA receptor encephalitis using intravenous immunoglobulin therapy became pregnant. Her pregnancy was uncomplicated with no relapses. She delivered at 35 4/7 weeks of gestation after having preterm premature rupture of membranes. She had a relapse of symptoms after delivery.

CONCLUSION:

This patient with anti-NMDA receptor encephalitis had an uneventful pregnancy with overall good outcome; however, she experienced relapse soon after delivery. This disease may mimic other autoimmune diseases, with improvement during pregnancy and risk for relapse postpartum.

• Authors: Joseph Magley, Dena Towner, Véronique Taché, Michelle L Apperson
• Journal: Obstetrics and gynecology (Obstet Gynecol) Vol. 120 Issue 2 Pt 2 Pg. 480-483 (Aug 2012) ISSN: 1873-233X [Electronic] United States
• PMID: 22825272 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunoglobulins, Intravenous

Topics

• Adult
• Anti-N-Methyl-D-Aspartate Receptor Encephalitis (diagnosis)
• Autoimmune Diseases (diagnosis)
• Female
• Fetal Membranes, Premature Rupture (etiology)
• Humans
• Immunoglobulins, Intravenous (administration & dosage)
• Infant, Newborn
• Infant, Premature
• Pregnancy
• Pregnancy Complications
• Pregnancy Outcome
• Recurrence
• Young Adult