Intralesional bleomycin for the treatment of periocular capillary hemangiomas.

Abstract

Periocular infantile capillary hemangiomas do not always respond well to conventional treatment modalities such as systemic or intralesional corticosteroids, radiotherapy or debulking surgery. The authors describe the use of intralesional bleomycin injections (IBIs) to treat potentially amblyogenic lesions in two cases where other modalities have failed. In both cases monthly IBIs successfully cleared the visual axis of the affected eye before the age of 1 year thus preventing permanent sensory deprivation amblyopia. A total of five and nine injections, respectively, were used and no significant side effects were noted. IBI appears to be a useful alternative in the treatment of periocular capillary hemangiomas refractory to more conventional modalities.

• Authors: Derrick P Smit, David Meyer
• Journal: Indian journal of ophthalmology (Indian J Ophthalmol) Vol. 60 Issue 4 Pg. 326-8 (Jul 2012) ISSN: 1998-3689 [Electronic] India
• PMID: 22824608 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Bleomycin

Topics

• Antibiotics, Antineoplastic (administration & dosage)
• Bleomycin (administration & dosage)
• Eyelid Neoplasms (diagnosis, drug therapy)
• Female
• Follow-Up Studies
• Hemangioma, Capillary (diagnosis, drug therapy)
• Humans
• Infant
• Injections, Intralesional
• Neoplastic Syndromes, Hereditary (diagnosis, drug therapy)