Abstract | BACKGROUND: METHODS: From August 2002 to January 2006, 27 newly diagnosed NPC patients who developed OME after a full course of radiotherapy were enrolled. Laser myringotomy was performed followed by once-weekly administration of steroids (0.5mL dexamethasone at a concentration of 5.0mg/mL) into the middle ear for 3 consecutive weeks. The success rate of dry eardrum perforation and the prognostic factors associated with OME resolution were analyzed. RESULTS: The procedure was performed on 44 ears of 27 patients. The mean follow-up period was 37 weeks. Of the 44 ears, 23 (52.3%) developed persistent eardrum perforation, 18 (40.9%) developed recurrent OME, and three (6.8%) were disease-free on follow-up. Of the 23 ears with persistent eardrum perforation, 18 (78.3%) were diagnosed as dry perforation. The absence of pretreatment mastoiditis was an independent factor associated with OME resolution (p<0.001). CONCLUSION: LMIS is a quick, minimally invasive, office-based technique that can be repeatedly performed to treat highly recurrent postirradiation OME, and it results in relatively slight pain to NPC patients. Long-lasting dry eardrum perforation allows for adequate middle ear ventilation and drainage and guarantees sustained relief from symptoms. The absence of preoperative mastoiditis is a favorable prognostic factor associated with OME resolution.
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Authors | Chin-Lung Kuo, Mao-Che Wang, Chia-Huei Chu, An-Suey Shiao |
Journal | Journal of the Chinese Medical Association : JCMA
(J Chin Med Assoc)
Vol. 75
Issue 7
Pg. 329-34
(Jul 2012)
ISSN: 1728-7731 [Electronic] Netherlands |
PMID | 22824047
(Publication Type: Journal Article)
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Copyright | Copyright © 2012. Published by Elsevier B.V. |
Chemical References |
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Topics |
- Adult
- Aged
- Carcinoma
- Dexamethasone
(administration & dosage)
- Female
- Humans
- Laser Therapy
- Male
- Middle Aged
- Nasopharyngeal Carcinoma
- Nasopharyngeal Neoplasms
(radiotherapy)
- Otitis Media with Effusion
(therapy)
- Radiotherapy
(adverse effects)
- Tympanic Membrane
(surgery)
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