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Exposure to residential radon and lung cancer in never-smokers: the preliminary results of the LCRINS study.

AbstractINTRODUCTION AND OBJECTIVE:
Residential radon is the second most important risk factor for lung cancer and the first among never-smokers. The objective of this study is to report the concentrations of residential radon in a series of never-smoker cases recruited in a multicenter study of cases and controls in northwestern Spain. In this study, all the hospitals in the Spanish province of Galicia and one from Asturias participated.
PATIENTS AND METHODS:
The present article includes a series of cases with residential radon measurements. All the subjects were personally interviewed, 3 ml of blood were taken from each, and they were each given instructions about how to place a residential radon detector in their homes.
RESULTS:
Sixty-nine case subjects were recruited, 84% of whom were women with a mean age of 71, and 81% of whom had adenocarcinoma. The average concentration of residential radon in the cases was 237 Bq/m(3), while the average concentration in the Galician population is 79 Bq/m(3). No relationship was observed between the concentration of residential radon and either sex or age at the time of diagnosis of the cases, but there was a tendency towards having a greater concentration in those diagnosed with small-cell and large-cell carcinoma.
CONCLUSIONS:
The concentrations of residential radon in the cases included are very high at about three times the average concentration of residential radon to which the general population of Galicia is exposed.
AuthorsAlberto Ruano-Ravina, Luciana Prini-Guadalupe, Juan Miguel Barros-Dios, José Abal-Arca, Virginia Leiro-Fernández, Ana Isabel González-Silva, Antonio Golpe-Gómez, Francisco Javier González-Barcala, Carolina Pena, Carmen Montero-Martínez, Cristina Martínez-González, María José Mejuto-Martí, Alejandro Veres-Racamonde
JournalArchivos de bronconeumología (Arch Bronconeumol) Vol. 48 Issue 11 Pg. 405-9 (Nov 2012) ISSN: 1579-2129 [Electronic] Spain
PMID22818755 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 SEPAR. Published by Elsevier España, S.L. All rights reserved.
Chemical References
  • Radon
Topics
  • Adenocarcinoma (epidemiology, etiology)
  • Adult
  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Carcinoma, Large Cell (epidemiology, etiology)
  • Carcinoma, Non-Small-Cell Lung (epidemiology, etiology)
  • Carcinoma, Small Cell (epidemiology, etiology)
  • Carcinoma, Squamous Cell (epidemiology, etiology)
  • Case-Control Studies
  • Dose-Response Relationship, Radiation
  • Environmental Exposure (adverse effects)
  • Female
  • Housing
  • Humans
  • Lung Neoplasms (epidemiology, etiology)
  • Male
  • Middle Aged
  • Neoplasms, Radiation-Induced (epidemiology, etiology)
  • Radiation Monitoring
  • Radon (adverse effects, analysis)
  • Sex Distribution
  • Spain (epidemiology)

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