Pregnancy associated brucellosis.

Abstract

Brucellosis zoonotic infection caused by Brucella spp. In endemic countries, the disease does not spare the pregnant. There is evidence that brucellosis can induce abortion in humans. Positive cultures of brucella from human placenta, aborted fetuses, and other products of conception were reported previously. It is speculated that brucellosis causes fewer spontaneous abortions in humans than animals due to the absence of Erythritol in the human placenta and fetus. In addition, the presence of anti-brucella activity in human amniotic fluid may also play a role. Rifampin is considered the mainstay of treatment of brucellosis during pregnancy, in various combinations. In a retrospective study of brucellosis in pregnancy, antepartum treatment with antimicrobial agents was more protective against the occurrence of abortion than no or inadequate treatment. It seems that the incidence of abortion is not different among patients treated with either trimethoprim-sulfamethoxazole with or without rifampicin. With therapy during pregnancy, the overall success rate resulting in normal delivery is 90%. The article discussed few of the patents associated with brucellosis.

• Authors: Jaffar A Al-Tawfiq, Ziad A Memish
• Journal: Recent patents on anti-infective drug discovery (Recent Pat Antiinfect Drug Discov) Vol. 8 Issue 1 Pg. 47-50 (Apr 2013) ISSN: 2212-4071 [Electronic] Netherlands
• PMID: 22812618 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Infective Agents
• Trimethoprim, Sulfamethoxazole Drug Combination
• Rifampin

Topics

• Abortion, Spontaneous (epidemiology, microbiology)
• Anti-Infective Agents (therapeutic use)
• Brucellosis (complications, drug therapy)
• Female
• Humans
• Patents as Topic
• Pregnancy
• Pregnancy Complications, Infectious (drug therapy, epidemiology, microbiology)
• Rifampin (therapeutic use)
• Trimethoprim, Sulfamethoxazole Drug Combination