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Autoimmune enteropathy: a review and update of clinical management.

Abstract
Autoimmune enteropathy (AIE) is a rare condition characterized by intractable diarrhea, histologic changes on small intestinal biopsy, and failed response to dietary manipulation that also may present with extraintestinal manifestations. In many patients, immunosuppressive therapies are necessary. Although AIE is more common in infants, adult involvement has also been documented. Much of what is known about AIE has been gathered from case reports and small case series; therefore, more research in this evolving field is needed. IPEX (immunodysregulation polyendocrinopathy enteropathy X-linked syndrome) and APECED (autoimmune phenomena, polyendocrinopathy, candidiasis, and ectodermal dystrophy) are systemic forms of AIE.
AuthorsNicole M Gentile, Joseph A Murray, Darrell S Pardi
JournalCurrent gastroenterology reports (Curr Gastroenterol Rep) Vol. 14 Issue 5 Pg. 380-5 (Oct 2012) ISSN: 1534-312X [Electronic] United States
PMID22810979 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Immunosuppressive Agents
Topics
  • Adult
  • Autoimmune Diseases (diagnosis, physiopathology, therapy)
  • Humans
  • Immunosuppressive Agents (therapeutic use)
  • Infant
  • Intestinal Diseases (diagnosis, immunology, therapy)
  • Parenteral Nutrition

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