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[A study of sympathetic skin response to the damage of autonomic nerves function in patients with chronic N-hexane poisoning].

AbstractOBJECTIVE:
To study the sympathetic skin response (SSR) to the effects of N-hexane on autonomic nerves function in patients with chronic N-hexane poisoning.
METHODS:
The subjects in present study included 30 controls and 37 cases with chronic N-hexane poisoning. Also 37 patients were divided into 3 subgroups (mild, moderate and severe poisoning) according to diagnostic criteria of occupational diseases. All subjects were examined by SSR test and nerve conduction velocity (NCV) test. All patients were reexamined by SSR and NCV every 1 ∼ 2 months. The differences in SSR parameters (latency, amplitude) among groups were observed. In the severe poisoning subgroup, the changes of SSR and NCV parameters (conduction velocity, amplitude) in different poisoning stages were observed.
RESULTS:
There were significant differences in SSR latency of upper extremity among groups and the significant differences in SSR amplitude of upper and lower extremity among groups (P < 0.05). No significant differences in SSR parameters were found between the adjacent groups (P > 0.05). There were significant differences in SSR latency of upper extremity during different periods and the significant differences in SSR amplitude of upper and lower extremity during different periods among all groups (P < 0.05). The change of SSR parameters consistent with that in NCV. The longest SSR latency of upper extremity and the smallest SSR amplitudes of upper and lower extremity appears 1 - 2 months earlier than that of the smallest action potential amplitude.
CONCLUSION:
The damage of autonomic nerves induced by N-hexane increased with poisoning progresses. The damage of autonomic nerves corresponded with the damage of myelin sheath of large myelinated nerves, but which appeared 1 - 2 months earlier than the damage of axon of large myelinated nerves. SSR test may serve as a method to detect the damage of autonomic nerves function in patients with chronic N-hexane poisoning.
AuthorsJie Situ, Jian Wu, Jing-lin Wang, De-xiang Zhu, Jian-jie Zhang, Wei-wei Liu, Zhuo-hui Qin
JournalZhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi) Vol. 30 Issue 5 Pg. 339-42 (May 2012) ISSN: 1001-9391 [Print] China
PMID22804985 (Publication Type: English Abstract, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Hexanes
  • n-hexane
Topics
  • Adolescent
  • Adult
  • Autonomic Pathways (physiopathology)
  • Case-Control Studies
  • Female
  • Galvanic Skin Response
  • Hexanes (poisoning)
  • Humans
  • Male
  • Neural Conduction
  • Occupational Diseases (physiopathology)
  • Skin (innervation, physiopathology)
  • Sympathetic Nervous System (physiopathology)
  • Young Adult

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