Protection of mice against infection with wild-type Mengo virus and an interferon sensitive mutant (IS-1) by polynucleotides and interferons.

Abstract

Single-stranded polynucleotide preparations [tRNA, poly(rI) plus poly(ho5C)-copolymer] which protect mice against picornavirus infections without inducing interferon, protected mice equally against infection with an interferon-sensitive mutant (IS-1) of Mengo virus and with wild-type virus (IS+). Poly(rI) . poly(rC), and mouse macrophage interferon [i.e. serum from mice treated with poly(rI) . poly(rC)] protected mice equally against infections with the two viruses, but fibroblast interferon protected better against infection with the interferon-sensitive mutant than with the wild-type virus. These and other results indicate that: Mengo virus had a genetic locus affecting sensitivity to fibroblast but not macrophage interferon; these two types of interferon have different mechanisms of action against Mengo virus infections in mice; Mengo virus genes controlling sensitivity to fibroblast interferon may modulate disease since infection in vivo induces only fibroblast interferon; the antiviral activity of the single-stranded polynucleotides is unlikely to be mediated by induction of either macrophage or fibroblast interferon.

• Authors: N Stebbing
• Journal: The Journal of general virology (J Gen Virol) Vol. 44 Issue 1 Pg. 255-60 (Jul 1979) ISSN: 0022-1317 [Print] England
• PMID: 227997 (Publication Type: Journal Article)

Chemical References

• RNA, Bacterial
• Interferons
• RNA, Transfer

Topics

• Animals
• Enterovirus Infections (prevention & control)
• Escherichia coli
• Fibroblasts
• Interferons (pharmacology)
• Macrophages
• Mengovirus (drug effects, genetics, growth & development)
• Mice
• Mutation
• RNA, Bacterial (pharmacology)
• RNA, Transfer (pharmacology)
• Species Specificity
• Virus Replication (drug effects)