Predictors of postoperative antimuscarinics in women with mixed urinary incontinence after transobturator surgery.

Abstract

INTRODUCTION AND HYPOTHESIS:

The study sought to identify the risk factors of postoperative use of antimuscarinics after transobturator surgery in women with mixed urinary incontinence (MUI) displaying both urodynamic stress urinary incontinence (SUI) and involuntary detrusor contraction (IDC) with leakage in urodynamic study.

METHODS:

The clinical data of 103 patients with MUI who underwent transobturator tape (TOT) sling surgery were retrospectively reviewed. The patients were followed at least a year. To determine risk factors for postoperative use of antimuscarinics, variables of only those with P values < 0.05 on univariate analysis were included in the multivariate logistic regression analysis with forward stepwise building.

RESULTS:

Eight-four (81.6 %) of 103 patients were included in this study. The cure rate of urge urinary incontinence (UUI) was 69.0 % (58/84). Antimuscarinics were prescribed postoperatively in 22 (26.2 %) of 84 patients. Variables affecting postoperative use of antimuscarinics were age, parity, episode of any UUI, preoperative use of antimuscarinics, predominant urgency incontinence type, detrusor pressure at maximum flow, and Urogenital Distress Inventory 6. Increasing age and preoperative use of antimuscarinics increased the odds of postoperative use of antimuscarinics following TOT surgery.

CONCLUSION:

Patients who were older and had taken antimuscarinics preoperatively were significantly associated with postoperative use of antimuscarinics.

• Authors: Eun-Hee Yoo, Donguk Kim
• Journal: International urogynecology journal (Int Urogynecol J) Vol. 24 Issue 3 Pg. 401-6 (Mar 2013) ISSN: 1433-3023 [Electronic] England
• PMID: 22797464 (Publication Type: Journal Article)

Chemical References

• Muscarinic Antagonists

Topics

• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Cohort Studies
• Female
• Follow-Up Studies
• Gynecologic Surgical Procedures
• Humans
• Incidence
• Middle Aged
• Muscarinic Antagonists (pharmacology, therapeutic use)
• Postoperative Period
• Retrospective Studies
• Risk Factors
• Suburethral Slings
• Urinary Bladder, Overactive (physiopathology, surgery)
• Urinary Incontinence (physiopathology, surgery)
• Urodynamics (drug effects, physiology)