Superior antimetastatic effect of pemetrexed-loaded gelatinase-responsive nanoparticles in a mouse metastasis model.

Abstract

Novel pemetrexed-loaded gelatinase-responsive nanoparticles were prepared as a targeted delivery system to determine its potential for clinical therapy of malignant melanoma. The pemetrexed-loaded poly(ethylene glycol)(PEG)-peptide-poly(ε-caprolactone) (PCL) nanoparticles included a gelatinase-cleavage peptide and a PEG-PCL-based structure. The pemetrexed-loaded PEG-peptide-PCL nanoparticles have shown the best antimetastatic effect in experimental lung metastasis models. The expressions of CD133 and thymidylate synthetase of metastatic tumors were also evaluated in our studies. Our results showed that pemetrexed-loaded gelatinase-responsive nanoparticles may represent a potent drug delivery system for inhibiting pulmonary metastasis and our preclinical results can provide new avenues for clinical therapy of malignant melanoma.

• Authors: Nannan Lu, Qin Liu, Rutian Li, Li Xie, Jie Shen, Wenxian Guan, Xiaoping Qian, Lixia Yu, Yitao Ding, Xiqun Jiang, Baorui Liu
• Journal: Anti-cancer drugs (Anticancer Drugs) Vol. 23 Issue 10 Pg. 1078-88 (Nov 2012) ISSN: 1473-5741 [Electronic] England
• PMID: 22797177 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• AC133 Antigen
• Antigens, CD
• Antineoplastic Agents
• Glutamates
• Glycoproteins
• Peptides
• Prom1 protein, mouse
• Pemetrexed
• Polyethylene Glycols
• Guanine
• Thymidylate Synthase
• Gelatinases

Topics

• AC133 Antigen
• Animals
• Antigens, CD (metabolism)
• Antineoplastic Agents (administration & dosage, chemistry, pharmacokinetics)
• Cell Line, Tumor
• Drug Delivery Systems (methods)
• Gelatinases (metabolism)
• Glutamates (administration & dosage, chemistry, pharmacokinetics)
• Glycoproteins (metabolism)
• Guanine (administration & dosage, analogs & derivatives, chemistry, pharmacokinetics)
• Lung (drug effects, pathology)
• Lung Neoplasms (drug therapy, pathology, secondary)
• Male
• Melanoma, Experimental (drug therapy, metabolism, pathology, secondary)
• Mice
• Mice, Inbred C57BL
• Nanoparticles (administration & dosage, chemistry)
• Neoplasm Metastasis
• Pemetrexed
• Peptides (metabolism)
• Polyethylene Glycols (administration & dosage, chemistry)
• Thymidylate Synthase (metabolism)