[Cigarette smoking and group I pepsinogen levels. Study in a normal population].

Abstract

Several studies have shown an influence of cigarette smoking on serum pepsinogen group I (PGI) levels in duodenal ulcer patients and in control subjects. The elevation of PGI in smokers has just been interpreted as reflecting some degree of smoking-induced inflammation of the gastric mucosa. We have determined fasting serum PGI by radioimmunoassay in 163 healthy subjects investigated by a survey conducted on a sample population of an urban area in the North-East of Italy by means of a random selection based on the public registers of home addresses. The data reported confirmed that PGI levels are increased by smoking in a healthy population. The main contribution of this study consists in demonstrating in a non-selected population an increase of the only parameter up to date claimed to be a possible serological predictive index for ulcer disease.

• Authors: B Germanà, F Di Mario, F Vianello, P Dotto, D Faggian, M Plebani, A Saggioro, R Naccarato
• Journal: Giornale di clinica medica (G Clin Med) 1990 Aug-Sep Vol. 71 Issue 8-9 Pg. 493-5 ISSN: 0017-0275 [Print] Italy
• Vernacular Title: Fumo di sigaretta e livelli di pepsinogeno del gruppo Io. Studio in una popolazione normale.
• PMID: 2279624 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Pepsinogens
• Peptide Fragments
• pepsinogen (1-12)
• Pepsinogen A

Topics

• Adult
• Aged
• Female
• Humans
• Italy
• Male
• Middle Aged
• Pepsinogen A
• Pepsinogens (blood)
• Peptic Ulcer (blood, etiology)
• Peptide Fragments (blood)
• Radioimmunoassay
• Risk Factors
• Sampling Studies
• Smoking (blood)