Abstract | INTRODUCTION: METHODS: RESULTS:
Endotoxins were detected in all root canals before instrumentation (S1). Group CLX + LW presented the greatest endotoxin reduction after instrumentation (99.18%), which was similar to group CLX + PmB (96.42%, P > .05) and different from group CLX (90.78%, P < .05). The intracanal medication promoted important endotoxin neutralization, with a reduction of 99.2% to 100%. The root canal content induced a higher production of tumor necrosis factor α and interleukin-1β in S1 samples compared with samples obtained after treatment. CONCLUSIONS: The combination of CLX and limewater as irrigant was the most effective in reducing endotoxins in root canals, and intracanal medication was important to neutralize the cytotoxic effects.
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Authors | Luciane Dias de Oliveira, Cláudio Antonio Talge Carvalho, Alessandra Sverberi Carvalho, Jéssica de Souza Alves, Marcia Carneiro Valera, Antonio Olavo Cardoso Jorge |
Journal | Journal of endodontics
(J Endod)
Vol. 38
Issue 8
Pg. 1053-7
(Aug 2012)
ISSN: 1878-3554 [Electronic] United States |
PMID | 22794204
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 American Association of Endodontists. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Endotoxins
- Interleukin-1beta
- Root Canal Irrigants
- Tumor Necrosis Factor-alpha
- Sodium Chloride
- Edetic Acid
- Polymyxin B
- Calcium Hydroxide
- Chlorhexidine
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Topics |
- Adult
- Animals
- Calcium Hydroxide
(therapeutic use)
- Cell Line
- Chlorhexidine
(therapeutic use)
- Dental Pulp Cavity
(drug effects)
- Dental Pulp Necrosis
(therapy)
- Edetic Acid
(therapeutic use)
- Endotoxins
(analysis, antagonists & inhibitors)
- Gram-Negative Bacteria
- Humans
- Interleukin-1beta
(analysis)
- Limulus Test
- Macrophages
(drug effects)
- Mice
- Middle Aged
- Periapical Periodontitis
(therapy)
- Polymyxin B
(therapeutic use)
- Root Canal Irrigants
(therapeutic use)
- Root Canal Therapy
(methods)
- Sodium Chloride
- Treatment Outcome
- Tumor Necrosis Factor-alpha
(analysis)
- Young Adult
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