Abstract | OBJECTIVE: DESIGN: SETTING: : One hundred four pediatric intensive care units in 18 countries. PATIENTS: Four hundred seventy-seven children between 38 wks corrected gestational age and 17 yrs with sepsis-induced cardiovascular and respiratory dysfunction. INTERVENTIONS: MEASUREMENTS AND MAIN RESULTS: CONCLUSIONS: While children in the RESOLVE trial were similar to adults in that they showed a relationship between severity of coagulation and inflammation abnormalities and mortality, their pharmacodynamic response to drotrecogin alfa (activated) differed with respect to changes in protein C activity and systemic inflammation.
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Authors | Heidi J Dalton, Joseph A Carcillo, D Bradley Woodward, Mary A Short, Mark D Williams |
Journal | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
(Pediatr Crit Care Med)
Vol. 13
Issue 6
Pg. 639-45
(Nov 2012)
ISSN: 1529-7535 [Print] United States |
PMID | 22791090
(Publication Type: Clinical Trial, Phase III, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Infective Agents
- Biomarkers
- Blood Proteins
- CALCA protein, human
- Cytokines
- Fibrin Fibrinogen Degradation Products
- Interleukin-1beta
- Interleukin-6
- Interleukin-8
- Protein C
- Protein Precursors
- Recombinant Proteins
- Tumor Necrosis Factor-alpha
- antithrombin III-protease complex
- fibrin fragment D
- Interleukin-10
- Antithrombin III
- Calcitonin
- Peptide Hydrolases
- drotrecogin alfa activated
- Calcitonin Gene-Related Peptide
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Topics |
- Adolescent
- Anti-Infective Agents
(therapeutic use)
- Antithrombin III
- Biomarkers
(blood)
- Blood Proteins
(metabolism)
- Calcitonin
(blood)
- Calcitonin Gene-Related Peptide
- Child
- Child, Preschool
- Cytokines
(blood)
- Disseminated Intravascular Coagulation
(blood, etiology, physiopathology)
- Double-Blind Method
- Female
- Fibrin Fibrinogen Degradation Products
(metabolism)
- Humans
- Infant
- Infant, Newborn
- Interleukin-10
(blood)
- Interleukin-1beta
(blood)
- Interleukin-6
(blood)
- Interleukin-8
(blood)
- Male
- Peptide Hydrolases
(blood)
- Protein C
(metabolism, therapeutic use)
- Protein Precursors
(blood)
- Recombinant Proteins
(therapeutic use)
- Respiratory Insufficiency
(etiology)
- Sepsis
(blood, complications, drug therapy)
- Survival Analysis
- Time Factors
- Tumor Necrosis Factor-alpha
(blood)
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