Abstract |
We evaluated the efficacy and safety of the epirubicin plus docetaxel(ET)regimen, which is a combination of active agents given to patients with inflammatory breast cancer(IBC)as a primary therapy. Nineteen patients received ET(60, 60mg/m2) every 3 weeks for 4 courses, and appropriate surgery was offered unless disease progression occurred. Seventeen patients completed the ET regimen and 1 patient was excluded because of no diffuse erythema, leaving 18 patients evaluable for the response and safety profile of this regimen. Grade 3/4 hematological toxicities were neutropenia in 15 patients(79%), febrile neutropenia in 8 patients(42%)and anemia in 3 patients(16%). Six patients(63%)received granulocyte colony-stimulating factor for febrile neutropenia. Febrile neutropenia was observed only for 1 course in all 6 patients and progression to apparent infection was not observed. Grade 3/4 non-hematological toxicities were constipation in 3, nausea in 2, anorexia in 2, fatigue in 1, vomiting in 1, diarrhea in 1, and stomatitis in 1 patient. The ET regimen was given to 16 patients(89%)as planned. The median number of courses was 4(range: 2-4). The clinical response rate was 44%. The median time to progression was 9 months, and median overall survival was 26 months. It is concluded that the ET regimen was well tolerated and effective as a primary chemotherapy for IBC.
|
Authors | Michiyo Saimura, Keisei Anan, Shoshu Mitsuyama, Satoshi Toyoshima, Koji Ikejiri, Tetsufumi Ohchi, Yoshiaki Rai, Tatsuji Oikawa, Manabu Kudaka, Reiki Nishimura, Shoji Kuroki, Kiyoshi Namba, Yuji Nakafusa, Kazuo Tamura |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 39
Issue 7
Pg. 1075-9
(Jul 2012)
ISSN: 0385-0684 [Print] Japan |
PMID | 22790042
(Publication Type: Journal Article, Multicenter Study)
|
Chemical References |
- Taxoids
- Docetaxel
- Epirubicin
|
Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Combined Modality Therapy
- Docetaxel
- Epirubicin
(administration & dosage, adverse effects)
- Female
- Humans
- Inflammatory Breast Neoplasms
(drug therapy, surgery)
- Middle Aged
- Taxoids
(administration & dosage, adverse effects)
|