Abstract | BACKGROUND:
Rosai-Dorfman disease is a rare condition characterized by an accumulation of histiocytes within lymph nodes and tissue. Treatment is indicated when the condition is highly symptomatic and when widespread involvement causes vital organ compression. OBJECTIVE: METHODS AND RESULTS: We describe a case of Rosai-Dorfman disease that failed to respond to monotherapy with systemic corticosteroids but improved with the addition of methotrexate. Methotrexate alone or in combination with other agents has been described in at least 12 other cases in the literature and lead to a partial or complete resolution of disease in over half of these. CONCLUSION:
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Authors | Eiman Nasseri, Annie Belisle, Deana Funaro |
Journal | Journal of cutaneous medicine and surgery
(J Cutan Med Surg)
2012 Jul-Aug
Vol. 16
Issue 4
Pg. 281-5
ISSN: 1203-4754 [Print] United States |
PMID | 22784522
(Publication Type: Case Reports, Journal Article, Review)
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Chemical References |
- Dermatologic Agents
- Glucocorticoids
- Prednisone
- Methotrexate
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Topics |
- Aged
- Dermatologic Agents
(administration & dosage, therapeutic use)
- Glucocorticoids
(administration & dosage, therapeutic use)
- Histiocytosis, Sinus
(drug therapy, pathology)
- Humans
- Male
- Methotrexate
(administration & dosage, therapeutic use)
- Prednisone
(administration & dosage, therapeutic use)
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