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Urea cycle disorder--argininosuccinic lyase deficiency.

Abstract
An increased level of ammonia in the bloodstream, or hyperammonemia, is a symptom associated with metabolic disorders referred to as inborn errors of metabolism. Urea cycle disorder is a congenital abnormality or absence of one of the six enzymes involved in the elimination of ammonia. Administration of certain medications, high protein diet, excessive exercise, surgical procedures, or trauma can precipitate symptoms of mental confusion, seizure-like activity, and ataxia. This paper reviews the literature with insight into current treatment and management options of the disorder and modification of treatment for the dental patient.
AuthorsNeeta Mehta, Pia Chatterjee Kirk, Ray Holder, Harry V Precheur
JournalSpecial care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry (Spec Care Dentist) 2012 Jul-Aug Vol. 32 Issue 4 Pg. 155-9 ISSN: 1754-4505 [Electronic] United States
PMID22784324 (Publication Type: Journal Article)
Copyright© 2012 Special Care Dentistry Association and Wiley Periodicals, Inc.
Chemical References
  • Pharmaceutical Preparations, Dental
  • Cytochrome P-450 CYP3A
Topics
  • Argininosuccinic Aciduria (complications, enzymology, pathology)
  • Cytochrome P-450 CYP3A (metabolism)
  • Dental Care for Chronically Ill
  • Drug Interactions
  • Humans
  • Hyperammonemia (complications)
  • Mouth Diseases (etiology, therapy)
  • Pharmaceutical Preparations, Dental (adverse effects)

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