Abstract | BACKGROUND: METHODS: RESULTS: One hundred and ninety-eight samples (72%) displayed positive membrane staining of the tumour cells, whereas 10 cases (4%) were borderline positive. EMMPRIN expression was associated with shorter metastasis-free, disease-specific and overall survival in both univariate and multivariate analyses. The prognostic impact was largely confined to TNM stage III, and EMMPRIN-negative stage III patients had an excellent prognosis. Furthermore, EMMPRIN was significantly associated with expression of S100A4, and the combined expression of these biomarkers conferred an even poorer prognosis. However, there was no evidence of direct regulation between the two proteins in the colorectal cancer cell lines HCT116 and SW620 in siRNA knockdown experiments. CONCLUSION:
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Authors | K Boye, J M Nesland, B Sandstad, M Haugland Haugen, G M Mælandsmo, K Flatmark |
Journal | British journal of cancer
(Br J Cancer)
Vol. 107
Issue 4
Pg. 667-74
(Aug 07 2012)
ISSN: 1532-1827 [Electronic] England |
PMID | 22782346
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- BSG protein, human
- Biomarkers, Tumor
- S100 Calcium-Binding Protein A4
- S100 Proteins
- Basigin
- S100A4 protein, human
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Topics |
- Adenocarcinoma
(metabolism, mortality, pathology)
- Adult
- Aged
- Aged, 80 and over
- Basigin
(metabolism)
- Biomarkers, Tumor
(metabolism)
- Cell Line, Tumor
- Colorectal Neoplasms
(metabolism, mortality, pathology)
- Female
- Gene Knockdown Techniques
- Humans
- Male
- Middle Aged
- Neoplasm Staging
- Prognosis
- S100 Calcium-Binding Protein A4
- S100 Proteins
(metabolism)
- Young Adult
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