Effect of substitution at N″-position of N'-hydroxy-N-amino guanidines on tumor cell growth.

Abstract

Structural modification of one of our earlier reported lead molecule (ABNM13) has been carried out to study the effect of different substituents at the N″-position of N-hydroxy-N'-amino guanidines (HAGs) on their anticancer activity. Compounds with electron donating substituents were found to be less active. In contrast, those with electron withdrawing groups were found favorable for anticancer activity. The obtained results provide significant SAR information that may be useful for further drug designing with HAGs.

• Authors: Arijit Basu, Barij Nayan Sinha, Philipp Saiko, Thomas Szekeres
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 22 Issue 15 Pg. 4934-8 (Aug 01 2012) ISSN: 1464-3405 [Electronic] England
• PMID: 22781189 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• Guanidines
• Ribonucleotide Reductases

Topics

• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Cell Proliferation (drug effects)
• Guanidines (chemical synthesis, chemistry, pharmacology)
• HL-60 Cells
• Humans
• Neoplasms (metabolism, pathology)
• Quantitative Structure-Activity Relationship
• Ribonucleotide Reductases (antagonists & inhibitors, metabolism)