Hyperlipidemia plays a vital role in
cardiovascular disease, and threatens our lives. The aim of this paper is to study the effects of
Shuanghua granules on blood
lipid in normal mice and different
hyperlipidemia models. Acute and endogenous
hyperlipidemia was induced in mice with yolk and
Triton WR-1339 respectively. The model of
hyperlipidemia in rats was set up by feeding high
cholesterol diet. Then preventive effects of
Shuanghua granules was observed compared with
lovastatin and Zhibituo. We found that
Shuanghua granules 5.6, 11.3, 22.5 g x kg (-1) could significantly reduce the serum TG level in normal mice (P < 0.01, P < 0.05). No significant difference was found in liver index, serum TG and HDL-C levels. When the mice were treated with either yolk or
Triton WR-1339 in the presence of
Shuanghua granules, the plasma
lipoprotein levels (TC and
LDL-C) were significantly reduced (P < 0.01, P < 0.05).
Shuanghua granules could reduce the serum TC, TG,
LDL-C, MDA,
NEFA and liver TC, TG,
LDL-C levels, simultaneously raise serum and liver HDL-C, serum SOD, LPL, HL, LA levels of
hyperlipidemia rats (P < 0.01, P < 0.05).
Shuanghua granules also significantly reduced whole blood viscosity, RV, etaP, IER and IEA (P < 0.01, P < 0.05), and lowered fatty degeneration of liver tissue. Compared with
hyperlipidemia model, there was no significant increase in faeces lipoids concentrations. The results confirmed the mechanism of blood
lipid regulating effects of
Shuanghua granules is probably related with its antioxidation, regulating hemorheology and improving LPA, HL, LA enzymatic activity.