Cytotoxic effect of eudesmanolides isolated from flowers of Tanacetum vulgare ssp. siculum.

Abstract

A phytochemical analysis of the dichloromethane extract from the flowers of a subspecies of Tanacetum vulgare growing in Sicily was carried out. Five known sesquiterpene lactones with the eudesmane skeleton have been isolated and the cytotoxic activity of these compounds was tested in vitro on A549 (human lung carcinoma epithelial-like) and V79379A (Chinese hamster lung fibroblast-like) cells using the tetrazolium salt reduction (MTT) assay. All of tested compounds induced high time- and concentration-dependent cytotoxic effects.

• Authors: Sergio Rosselli, Maurizio Bruno, Francesco Maria Raimondo, Vivienne Spadaro, Mehmet Varol, Ayşe Tansu Koparal, Antonella Maggio
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 17 Issue 7 Pg. 8186-95 (Jul 09 2012) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 22777187 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Sesquiterpenes
• eudesmanolide

Topics

• Animals
• Cell Death (drug effects)
• Cell Line
• Cell Proliferation (drug effects)
• Colorimetry
• Flowers (chemistry)
• Humans
• Inhibitory Concentration 50
• Sesquiterpenes (chemistry, isolation & purification, pharmacology)
• Tanacetum (chemistry)