[Clinicopathological and immunohistochemical study on penetrating and superficial spreading type of early gastric cancers].

Abstract

Specific type of early gastric cancer based on the cancer surface area and the degree of invasion were studied by measuring digital values of the cancer surface area in early gastric cancer patients. The results indicated that the pen and super type of early gastric cancer had many clinicopathological characteristics as compared with common type of early gastric cancer. An immunohistochemical study also revealed that the pen type of early gastric cancer had a high growth activity. Moreover, it was suggested that EGF was involved in its specific invasion and growth, and that EGF and TGF-beta affected its scirrhous growth. The possibility that the poorly differentiated pen type is an early lesion of linitis plastica type gastric cancer was also considered. From these findings, it was assumed that the immunological staining of EGF and TGF-beta in biopsy specimens might be useful in the diagnosis of the pen type of early gastric cancer and also in diagnosis of early lesion of linitis plastica type gastric cancer.

• Authors: D Hirayama, T Fujimori, M Arao, S Maeda
• Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology (Nihon Shokakibyo Gakkai Zasshi) Vol. 87 Issue 11 Pg. 2434-43 (Nov 1990) ISSN: 0446-6586 [Print] Japan
• PMID: 2277434 (Publication Type: English Abstract, Journal Article)

Chemical References

• Transforming Growth Factor beta
• Epidermal Growth Factor

Topics

• Epidermal Growth Factor (metabolism)
• Humans
• Immunohistochemistry
• Neoplasm Invasiveness
• Stomach Neoplasms (metabolism, pathology)
• Transforming Growth Factor beta (metabolism)