Intercellular communication in sensory ganglia by purinergic receptors and gap junctions: implications for chronic pain.

Abstract

Peripheral injury can cause abnormal activity in sensory neurons, which is a major factor in chronic pain. Recent work has shown that injury induces major changes not only in sensory neurons but also in the main type of glial cells in sensory ganglia-satellite glial cells (SGCs), and that interactions between sensory neurons and SGCs contribute to neuronal activity in pain models. The main functional changes observed in SGCs after injury are an increased gap junction-mediated coupling among these cells, and augmented sensitivity to ATP. There is evidence that the augmented gap junctions contribute to neuronal hyperexcitability in pain models, but the mechanism underlying this effect is not known. The changes in SGCs described above have been found following a wide range of injuries (both axotomy and inflammation) in somatic, orofacial and visceral regions, and therefore appear to be a general feature in chronic pain. We have found that in cultures of sensory ganglia calcium signals can spread from an SGC to neighboring cells by calcium waves, which are mediated by gap junctions and ATP acting on purinergic P2 receptors. A model is proposed to explain how augmented gap junctions and greater sensitivity to ATP can combine to produce enhanced calcium waves, which can lead to neuronal excitation. Thus this simple scheme can account for several major changes in sensory ganglia that are common to a great variety of pain models.

• Authors: Menachem Hanani
• Journal: Brain research (Brain Res) Vol. 1487 Pg. 183-91 (Dec 03 2012) ISSN: 1872-6240 [Electronic] Netherlands
• PMID: 22771859 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2012 Elsevier B.V. All rights reserved.

Chemical References

• Receptors, Purinergic
• Receptors, Purinergic P2

Topics

• Animals
• Calcium Signaling (physiology)
• Cell Communication (physiology)
• Chronic Pain (physiopathology)
• Ganglia, Sensory (injuries, physiology)
• Gap Junctions (physiology)
• Humans
• Neuroglia (physiology)
• Receptors, Purinergic (physiology)
• Receptors, Purinergic P2 (physiology)
• Satellite Cells, Perineuronal (physiology)
• Sensory Receptor Cells (metabolism, physiology)