Abstract | BACKGROUND: Transcatheter aortic bioprosthesis implantation is a new treatment modality for patients with aortic stenosis who are inoperable or at high surgical risk. OBJECTIVE: To report the three-year experience with transcatheter CoreValve® bioprosthesis implantation. METHODS: From January 2008 to January 2011, 35 patients with aortic stenosis (33) or aortic valve bioprosthesis dysfunction (two) at high surgical risk underwent transcatheter CoreValve® bioprosthesis implantation. RESULTS: The patients' mean age was 81.5 ± 9 years, and 80% had heart failure functional class III or IV. The EuroScore was 18.4 ± 14.3% and the STS risk score was 14.5 ± 11.6%. Successful device implantation was achieved in 34 (97.1%) patients. After the intervention, a reduction in the transvalvular pressure gradient from 84.9 ± 22 to 22.5 ± 9.5 mm Hg was observed, and 87.1% of the patients progressed to functional class I or II. Thirty-day mortality and mortality in the follow-up of 400 ± 298 days were 11.4% and 31.4%, respectively. The occurrence of life-threatening hemorrhagic complications was the only independent predictor of cardiovascular mortality. Stroke occurred in 5.7% of the patients. Permanent pacemaker was required in 32.1% of the patients within the first month after the procedure. CONCLUSION: Transcatheter aortic bioprosthesis implantation is a safe and effective procedure to be used in patients with aortic stenosis at high surgical risk. The CoreValve® prosthesis proved to have mid-term efficacy in a three-year follow-up.
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Authors | Fabio Sandoli de Brito Junior, Alexandre Abizaid, Breno O Almeida, Adriano Caixeta, Flávio Tarasoutchi, Eberhard Grube, Marco Perin |
Journal | Arquivos brasileiros de cardiologia
(Arq Bras Cardiol)
Vol. 99
Issue 2
Pg. 697-705
(Aug 2012)
ISSN: 1678-4170 [Electronic] Brazil |
PMID | 22766918
(Publication Type: Journal Article)
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Topics |
- Aged
- Aged, 80 and over
- Aortic Valve Stenosis
(therapy)
- Bioprosthesis
- Cardiac Catheterization
(adverse effects, methods)
- Endpoint Determination
- Epidemiologic Methods
- Female
- Heart Valve Prosthesis
- Heart Valve Prosthesis Implantation
(adverse effects, methods)
- Humans
- Male
- Middle Aged
- Postoperative Complications
- Treatment Outcome
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