Abstract | INTRODUCTION: The benzoporphyrine derivative verteporfin has lost its importance to the treatment of the most frequent neovascular eye diseases. Nevertheless, it is still mandatory to define the remaining applications, role, and potential of verteporfin in ocular photodynamic therapy ( PDT), including the dosages of administration, effectiveness, and safety profile. AREAS COVERED: EXPERT OPINION: Evidence-based data regarding optimized parameters (low fluence, reduced dose, fractionated irradiation) adapted to the treated diseases (target structure, dosimetry, blood supply) are scarce. Prospective and large clinical trials are missing, although the scientific community agrees on the fact that the standard treatment protocol does not necessarily provide the optimal efficacy to the specific disease or individual patient. Within the reviewed indications, the adverse effect profile is favorable compared with other therapies.
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Authors | Focke Ziemssen, Heinrich Heimann |
Journal | Expert opinion on drug metabolism & toxicology
(Expert Opin Drug Metab Toxicol)
Vol. 8
Issue 8
Pg. 1023-41
(Aug 2012)
ISSN: 1744-7607 [Electronic] England |
PMID | 22762303
(Publication Type: Journal Article, Review)
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Chemical References |
- Photosensitizing Agents
- Porphyrins
- Verteporfin
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Topics |
- Central Serous Chorioretinopathy
(drug therapy, physiopathology)
- Choroid Neoplasms
(drug therapy, physiopathology)
- Choroidal Neovascularization
(drug therapy, physiopathology)
- Drug Evaluation
- Hemangioma
(drug therapy, physiopathology)
- Humans
- Neovascularization, Pathologic
(drug therapy, physiopathology)
- Ophthalmology
(methods)
- Photochemotherapy
(methods)
- Photosensitizing Agents
(pharmacokinetics, pharmacology)
- Porphyrins
(pharmacokinetics, pharmacology)
- Randomized Controlled Trials as Topic
- Treatment Outcome
- Verteporfin
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