Nectin4 is an epithelial cell receptor for canine distemper virus and involved in neurovirulence.

Abstract

Canine distemper virus (CDV) uses signaling lymphocyte activation molecule (SLAM), expressed on immune cells, as a receptor. However, epithelial and neural cells are also affected by CDV in vivo. Wild-type CDV strains showed efficient replication with syncytia in Vero cells expressing dog nectin4, and the infection was blocked by an anti-nectin4 antibody. In dogs with distemper, CDV antigen was preferentially detected in nectin4-positive neurons and epithelial cells, suggesting that nectin4 is an epithelial cell receptor for CDV and also involved in its neurovirulence.

• Authors: Watanyoo Pratakpiriya, Fumio Seki, Noriyuki Otsuki, Kouji Sakai, Hideo Fukuhara, Hiromu Katamoto, Takuya Hirai, Katsumi Maenaka, Somporn Techangamsuwan, Nguyen Thi Lan, Makoto Takeda, Ryoji Yamaguchi
• Journal: Journal of virology (J Virol) Vol. 86 Issue 18 Pg. 10207-10 (Sep 2012) ISSN: 1098-5514 [Electronic] United States
• PMID: 22761370 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, Viral
• Cell Adhesion Molecules
• Nectins
• Receptors, Virus

Topics

• Animals
• Antigens, Viral (metabolism)
• Cell Adhesion Molecules (physiology)
• Chlorocebus aethiops
• Distemper (virology)
• Distemper Virus, Canine (immunology, pathogenicity, physiology)
• Dogs
• Host-Pathogen Interactions (physiology)
• Nectins
• Neurons (virology)
• Receptors, Virus (physiology)
• Vero Cells
• Virulence (physiology)