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[Isotretinoin embryopathy with microtia-anotia and congenital heart disease: case report].

Abstract
Isotretinoin is a retinoid that derivates from vitamin A. It is indicated for recalcitrant nodular acne treatment, but it has been classified as teratogenic. A wide spectrum of birth defects including craniofacial, heart and nervous system malformations have been described associated to prenatal exposure to this drug. We report the case of a newborn with a history of prenatal exposure to isotretinoin with craniofacial defects, including facial paralysis, right anotia, left microtia and complex heart disease. Key words: isotretinoin, congenital abnormalities, teratology.
AuthorsHarry Pachajoa, Adriana Ordoñez
JournalArchivos argentinos de pediatria (Arch Argent Pediatr) 2012 May-Jun Vol. 110 Issue 3 Pg. e47-9 ISSN: 1668-3501 [Electronic] Argentina
Vernacular TitleEmbriopatía por isotretinoína con microtia-anotia y cardiopatía: Presentación de un caso.
PMID22760759 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Isotretinoin
Topics
  • Abnormalities, Drug-Induced (etiology)
  • Abnormalities, Multiple (chemically induced)
  • Congenital Abnormalities (etiology)
  • Congenital Microtia
  • Ear (abnormalities)
  • Female
  • Heart Defects, Congenital (chemically induced)
  • Humans
  • Infant, Newborn
  • Isotretinoin (adverse effects)

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