A complete response to S-1 plus cis-diamminedichloroplatinum in advanced-stage esophageal and gastric adenocarcinoma: a case report.

Abstract

BACKGROUND:

Complete remission from advanced-stage synchronous double primary (SDP) esophageal and gastric adenocarcinoma by chemotherapy alone is rare. We report a case of advanced-stage SDP esophageal and gastric adenocarcinoma in which a complete response to treatment was obtained with S-1 and cis-diamminedichloroplatinum (CDDP).

CASE PRESENTATION:

The patient was a 74-year-old man referred to our hospital complaining of dysphagia. Gastrointestinal endoscopy was performed and advanced-stage SDP esophageal and gastric adenocarcinoma diagnosed. Computed tomography revealed multiple regional lymph node metastases in the mediastinum. Neoadjuvant chemotherapy with S-1 and CDDP for advanced esophageal and gastric cancer was planned. An endoscopy following two courses of chemotherapy revealed that the esophageal cancer had been replaced with a normal mucosal lesion and the gastric tumor with a scar lesion; the results of biopsies of both were negative for cancer. Computed tomography revealed that the multiple lymph node metastases had disappeared. We diagnosed a complete response to S-1 and CDDP in advanced-stage SDP esophageal and gastric cancer. The patient is still alive with no signs of recurrence 22  months after the disappearance of the original tumor and metastatic lesions without surgical treatment.

CONCLUSION:

These results suggest that complete remission from advanced-stage esophageal and gastric cancer can be obtained with chemotherapy with S-1 plus CDDP.

• Authors: Yoritaka Matsuno, Mitsugu Kochi, Masashi Fujii, Noriaki Kanamori, Teruo Kaiga, Yoshiaki Mihara, Tomoya Funada, Teruyuki Miyazaki, Tadatoshi Takayama
• Journal: World journal of surgical oncology (World J Surg Oncol) Vol. 10 Pg. 133 (Jul 03 2012) ISSN: 1477-7819 [Electronic] England
• PMID: 22759597 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Drug Combinations
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Cisplatin

Topics

• Adenocarcinoma (drug therapy, pathology)
• Aged
• Antimetabolites, Antineoplastic (therapeutic use)
• Cisplatin (therapeutic use)
• Disease Progression
• Drug Combinations
• Drug Therapy, Combination
• Esophageal Neoplasms (drug therapy, pathology)
• Humans
• Male
• Oxonic Acid (therapeutic use)
• Stomach Neoplasms (drug therapy, pathology)
• Tegafur (therapeutic use)
• Treatment Outcome