Tegafur-uracil is a safe alternative for the treatment of colorectal cancer in patients with partial dihydropyrimidine dehydrogenase deficiency: a proof of principle.

Abstract

OBJECTIVE:

The objective of this study was to evaluate the safety of using tegafur-uracil (UFT) in colorectal cancer patients with partial dihydropyrimidine dehydrogenase (DPD) deficiency.

PATIENTS AND METHODS:

The study included five colorectal cancer patients who presented with acute toxicity (grades 3 and 4) after being given the first cycle of chemotherapy using 5-fluorouracil. The DPD deficiency was confirmed by gene sequencing. After a full recovery from all side effects, we changed the regimen to UFT (300 mg/m(2)/day) associated with leucovorin (90 mg/day) for 21 days, with an empirical dose reduction of at least 10% in the first cycle.

RESULTS:

We prospectively analysed 22 UFT cycles in 5 patients. We did not observe any episodes of grade 3 or 4 toxicity. The predominant toxicities were of grades 1 and 2 (nausea, vomiting and diarrhoea).

CONCLUSION:

Here, we demonstrate a complete absence of severe toxicity in all patients and cycles analysed. We believe that UFT is a safe alternative for the treatment of patients with partial DPD deficiency.

• Authors: Daniel I G Cubero, Felipe Melo Cruz, Patrícia Santi, Ismael Dale C G Silva, Auro Del Giglio
• Journal: Therapeutic advances in medical oncology (Ther Adv Med Oncol) Vol. 4 Issue 4 Pg. 167-72 (Jul 2012) ISSN: 1758-8359 [Electronic] England
• PMID: 22754590 (Publication Type: Journal Article)