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Blood vessel normalization in the hamster oral cancer model for experimental cancer therapy studies.

AbstractBACKGROUND:
Normalization of tumor blood vessels improves drug and oxygen delivery to cancer cells. The aim of this study was to develop a technique to normalize blood vessels in the hamster cheek pouch model of oral cancer.
MATERIALS AND METHODS:
Tumor-bearing hamsters were treated with thalidomide and were compared with controls.
RESULTS:
Twenty eight hours after treatment with thalidomide, the blood vessels of premalignant tissue observable in vivo became narrower and less tortuous than those of controls; Evans Blue Dye extravasation in tumor was significantly reduced (indicating a reduction in aberrant tumor vascular hyperpermeability that compromises blood flow), and tumor blood vessel morphology in histological sections, labeled for Factor VIII, revealed a significant reduction in compressive forces. These findings indicated blood vessel normalization with a window of 48 h.
CONCLUSION:
The technique developed herein has rendered the hamster oral cancer model amenable to research, with the potential benefit of vascular normalization in head and neck cancer therapy.
AuthorsAna J Molinari, Romina F Aromando, Maria E Itoiz, Marcela A Garabalino, Andrea Monti Hughes, Elisa M Heber, Emiliano C C Pozzi, David W Nigg, Verónica A Trivillin, Amanda E Schwint
JournalAnticancer research (Anticancer Res) Vol. 32 Issue 7 Pg. 2703-9 (Jul 2012) ISSN: 1791-7530 [Electronic] Greece
PMID22753729 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Angiogenesis Inhibitors
  • Thalidomide
Topics
  • Angiogenesis Inhibitors (pharmacology)
  • Animals
  • Blood Vessels (drug effects, pathology)
  • Capillary Permeability (drug effects)
  • Case-Control Studies
  • Cheek (blood supply, pathology)
  • Cricetinae
  • Disease Models, Animal
  • Mesocricetus
  • Microscopy (methods)
  • Mouth Neoplasms (blood supply, drug therapy, therapy)
  • Neovascularization, Pathologic (pathology)
  • Precancerous Conditions (blood supply)
  • Thalidomide (pharmacology)

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