Abstract | BACKGROUND: Normalization of tumor blood vessels improves drug and oxygen delivery to cancer cells. The aim of this study was to develop a technique to normalize blood vessels in the hamster cheek pouch model of oral cancer. MATERIALS AND METHODS:
Tumor-bearing hamsters were treated with thalidomide and were compared with controls. RESULTS: Twenty eight hours after treatment with thalidomide, the blood vessels of premalignant tissue observable in vivo became narrower and less tortuous than those of controls; Evans Blue Dye extravasation in tumor was significantly reduced (indicating a reduction in aberrant tumor vascular hyperpermeability that compromises blood flow), and tumor blood vessel morphology in histological sections, labeled for Factor VIII, revealed a significant reduction in compressive forces. These findings indicated blood vessel normalization with a window of 48 h. CONCLUSION:
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Authors | Ana J Molinari, Romina F Aromando, Maria E Itoiz, Marcela A Garabalino, Andrea Monti Hughes, Elisa M Heber, Emiliano C C Pozzi, David W Nigg, Verónica A Trivillin, Amanda E Schwint |
Journal | Anticancer research
(Anticancer Res)
Vol. 32
Issue 7
Pg. 2703-9
(Jul 2012)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 22753729
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Angiogenesis Inhibitors
- Thalidomide
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Topics |
- Angiogenesis Inhibitors
(pharmacology)
- Animals
- Blood Vessels
(drug effects, pathology)
- Capillary Permeability
(drug effects)
- Case-Control Studies
- Cheek
(blood supply, pathology)
- Cricetinae
- Disease Models, Animal
- Mesocricetus
- Microscopy
(methods)
- Mouth Neoplasms
(blood supply, drug therapy, therapy)
- Neovascularization, Pathologic
(pathology)
- Precancerous Conditions
(blood supply)
- Thalidomide
(pharmacology)
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